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VU591 hydrochloride
CAS No. 1315380-70-1
VU591 hydrochloride( —— )
Catalog No. M22454 CAS No. 1315380-70-1
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM).?Thought to block the intracellular pore of the Kir1.1 channel.?Exhibits no effect on Kir7.1 at concentrations up to 10 μM;?does not inhibit Kir2.1, Kir2.3 or Kir4.1.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 335 | In Stock |
|
| 10MG | 494 | In Stock |
|
| 25MG | 782 | In Stock |
|
| 50MG | 1053 | In Stock |
|
| 100MG | 1422 | In Stock |
|
| 500MG | 2853 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU591 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionVU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM).?Thought to block the intracellular pore of the Kir1.1 channel.?Exhibits no effect on Kir7.1 at concentrations up to 10 μM;?does not inhibit Kir2.1, Kir2.3 or Kir4.1.?
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DescriptionVU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM).?Thought to block the intracellular pore of the Kir1.1 channel.?Exhibits no effect on Kir7.1 at concentrations up to 10 μM;?does not inhibit Kir2.1, Kir2.3 or Kir4.1.?Displays similar potency to VU 590?.
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In VitroVU591 hydrochloride is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.
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In VivoVU591 hydrochloride (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST. Animal Model:Male ICR miceDosage:1.842 μg Administration:i.c.v.; 1.842 μg Result:Showed antidepressive effect in the tail suspension test (TST).
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorKir1.1
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Research Area——
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Indication——
Chemical Information
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CAS Number1315380-70-1
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Formula Weight404.76
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Molecular FormulaC16H13ClN6O5
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Purity>98% (HPLC)
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SolubilityDMSO:16 mg/mL (39.53 mM; Need ultrasonic)
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SMILESCl.[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.
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